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    Information and Uses
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Zenpep (pancrelipase) Delayed-Release Capsules
  • What Is EPI?
  • How ZENPEP Works
  • Getting Started
    • Get Started Simply
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    • Dosing for Infants
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  • IMPORTANT SAFETY INFORMATION
  • PRESCRIBING INFORMATION
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  • ZENPEP PATIENT SUPPORT PROGRAMS
  • What Is EPI?
  • How ZENPEP Works
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    • Dosing for Infants
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    • Patient Resources
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IMPORTANT RISK INFORMATION
AND USES

INDICATION

ZENPEP is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes.

IMPORTANT SAFETY INFORMATION

ZENPEP may increase your chance of having a rare bowel disorder called fibrosing colonopathy.

Call your doctor if you have unusual or severe stomach area pain, bloating, trouble passing stool, nausea, vomiting, or diarrhea.

Take ZENPEP exactly as your doctor tells you. Do not take more ZENPEP than directed by your doctor.

Always take ZENPEP with a meal or snack. ZENPEP capsules should be swallowed whole. Do not crush or chew the ZENPEP capsules or its contents and do not hold the capsule contents in your mouth.

ZENPEP may cause serious side effects, including:

  • Irritation of the inside of your mouth
  • Increase in blood uric acid levels
  • Severe allergic reactions

The most common side effects of ZENPEP include:

  • Headache
  • Bruising
  • Cough
  • Feeling full after eating a small amount of food.

Tell your doctor if you are allergic to pork products, have kidney disease, are pregnant or plan to become pregnant or are breastfeeding.

Please also see Medication Guide and the full Prescribing Information.

Nestlé Health Science

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©2025 Nestlé.

The product information provided in this site is intended for
residents of the United States.

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The health information described on this site is provided for educational purposes only and is not intended to substitute discussions with a healthcare provider.

ZP-PM-USA-0085 02/25

Program Terms, Conditions, and Eligibility Criteria:

  1. This offer is good for use only with a valid prescription for ZENPEP® (pancrelipase) Delayed-Release Capsules at the time the prescription is filled by the pharmacist and dispensed to the patient.
  2. Depending on your insurance coverage, most eligible patients may pay as little as $5 for the first ZENPEP prescription and for each refill of ZENPEP. Check with your pharmacist for your copay discount. Maximum savings limit applies; patient out-of-pocket expense may vary.
  3. This offer is not valid for use by patients enrolled in, nor shall the copay prescription be submitted for reimbursement to, Medicare (including Medicare Advantage), Medicaid (including managed Medicaid plans), Medigap, TRICARE, or other federal or state programs (including any state pharmaceutical assistance programs), or private indemnity or HMO insurance plans that reimburse you for the entire cost of your prescription drugs. Patients may not use this card if they are Medicare-eligible and enrolled in an employer-sponsored health plan or prescription drug benefit program for retirees. This offer is not valid for cash-paying patients.
  4. This offer is valid for up to twelve (12) prescription fills of a 30-day supply or up to four (4) prescription fills for a 90-day supply. Offer applies only to prescriptions filled before the program expires on April 30, 2026.
  5. Nestlé reserves the right to rescind, revoke, or amend this offer without notice.
  6. Offer good only in the USA, including Puerto Rico, at participating retail pharmacies.
  7. For California and Massachusetts residents, benefits pursuant to this card will terminate automatically upon the introduction of a therapeutically equivalent product.
  8. Void if prohibited by law, taxed, or restricted.
  9. This card is not transferable. The selling, purchasing, trading, or counterfeiting of this card is prohibited by law.
  10. This card has no cash value and may not be used in combination with any other discount, coupon, rebate, free trial, or similar offer for the specified prescription.
  11. This offer is not health insurance.
  12. This card expires April 30, 2026.
  13. Certain information related to your use of the card may be collected, analyzed, and shared with Nestlé for market research and other purposes related to assess Nestlé’s programs. Information shared with Nestlé will be aggregated and deidentified; it will be combined with other data related to other card redemptions and will not identify you. By redeeming this card, you acknowledge that you are an eligible patient and that you understand and agree to comply with the terms and conditions of this offer.

For questions about the program, please call 1-833-742-0707.

Pharmacist Instructions for a Patient with an Eligible Third Party Payer:

When you redeem this card, you certify that you have not submitted and will not submit a claim for reimbursement under any federal, state, or other government programs for this prescription. Submit the claim to the primary Third Party Payer first, then submit the balance due to PDMI using BIN# 610020 as a Secondary Payer COB with patient responsibility amount and a valid Other Coverage Code (eg, 8). If you receive a rejection due to PA, step-edit, or NDC block, submit Other Coverage Code of 03 (secondary claim). The patient’s out-of-pocket expense will be reduced up to the maximum savings limit for the program. Reimbursement will be received from PDMI. For help processing this card, call 1-833-742-0707. Representatives are available Monday through Friday, 8AM–8PM EST, except for major holidays.

Program managed by Mercalis on behalf of Nestlé Health Science.

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