Dosing in Patients Without CF
ZENPEP Dosing Guide for 40,000 Lipase-Unit Capsules
Capsules not actual size. K=1,000.
- This chart is intended to be a guide; ZENPEP capsules represent nearest capsule count within recommended dosing range
- The dose of ZENPEP should be individualized based on weight, clinical symptoms, the degree of steatorrhea present, and the fat contents of the patient’s diet1
- Dosing should not exceed the recommended maximum dosage set forth by the Cystic Fibrosis Foundation Conferences Guidelines1
Only ZENPEP 40,000 lipase units meets American College of Gastroenterology (ACG) per-meal recommendations for EPI in just 1 capsule2
ZENPEP contains the widest range of doses—including the highest strength available1
This may allow for customized dosing and may reduce the number of capsules needed.
Challenges with PERT include underdosing, pill burden, and patient compliance3,4
ZENPEP dosing with 40,000-unit capsules may help.1,5
- Dosing range is 500 to 2,500 lipase units/kg/meal (children ≥4 years and adults)
- Patients may be dosed on a fat ingestion–based or an actual body weight–based dosing scheme
A healthy pancreas produces between 480,000 and 720,000 lipase units per meal6*
The ACG recommends PERT in patients with CP and EPI. Therapy should include an adequate dosage of at least 40,000 to 50,000 lipase units per meal.2
*The estimated “normal” amount of pancreatic enzyme secretion 2 hours after a meal varies with content and volume of meal ingested. Data estimated from studies using test meals of 300 to 600 k/cal.
CF=cystic fibrosis; CP=chronic pancreatitis; EPI=exocrine pancreatic insufficiency; PERT=pancreatic enzyme replacement therapy.
ZENPEP Dosing Calculator
Calculate the ZENPEP dose in 3 easy steps.
Use the app below to calculate the per-meal ZENPEP dose for your patients with EPI due to CF or other conditions. ZENPEP is not interchangeable with any other pancrelipase product. Therapy should be initiated at the lowest recommended dose and gradually increased. The dosage of ZENPEP should be individualized based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet. Dosing should not exceed the recommended maximum dosage set forth by the Cystic Fibrosis Foundation Consensus Conferences Guidelines.
Step 1 / Patient Age
Step 2 / Weight or Dietary Fat-Based Dosing
Step 3 / Recommended Lipase Units/kg Body
Step 4 / Result!
DISCLAIMER: By using this dosing calculator, you agree to the following: The dosing calculator is being provided "AS IS" and is intended for healthcare professional (HCP) use only. The dosing calculator is to be used only in conjunction with ZENPEP (pancrelipase) delayed-release capsules. All calculations should be confirmed before use. The information being provided is not a substitute for clinical judgment. While the tool attempts to be as accurate as possible, it should not be relied upon as being comprehensive and error-free. Neither Nestlé Health Science, nor any party involved in the publication of this site, shall be liable to you or others for any decisions made or actions taken by you or others in reliance of this information. The user assumes all responsibility and risk for the use of this tool.
If you are not an HCP and have questions about ZENPEP dosing, please contact your HCP.
References: 1. ZENPEP. Package insert. Nestlé Health Science; 2020. 2. Gardner TB, Adler DG, Forsmark CE, Sauer BG, Taylor JR, Whitcomb DC. ACG Clinical Guideline: chronic pancreatitis. Am J Gastroenterol. 2020;115(3):322-339. doi:10.14309/ajg.0000000000000535 3. Perbtani Y, Forsmark CE. Update on the diagnosis and management of exocrine pancreatic insufficiency. F1000Res. 2019;8:F1000 Faculty Rev-1991. doi:10.12688/f1000research.20779.1 4. Brennan GT, Saif MW. Pancreatic enzyme replacement therapy: a concise review. JOP. 2019;20(5):121-125. 5. Wooldridge JL, Heubi JE, Amaro-Galvez R, et al. EUR-1008 pancreatic enzyme replacement is safe and effective in patients with cystic fibrosis and pancreatic insufficiency. J Cyst Fibros. 2009;8(6):405-417. doi:10.1016/j.jcf.2009.07.006 6. Keller J, Layer P. Human pancreatic exocrine response to nutrients in health and disease. Gut. 2005;54(suppl6):vi1-vi28. doi:10.1136/gut.2005.065946