Dosing in Patients With CF
Each ZENPEP capsule strength contains the specified amounts of lipase, protease, and amylase1
Capsules not actual size. K=1,000.
- ZENPEP is not interchangeable with any other pancrelipase product
- ZENPEP capsules and capsule contents should not be crushed or chewed
- ZENPEP should be taken with every meal and snack. Usually, half of the prescribed dose for an individualized full meal should be given with each snack
- Therapy should be initiated at the lowest recommended dose and gradually increased
CF=cystic fibrosis; EPI=exocrine pancreatic insufficiency; PERT=pancreatic enzyme replacement therapy.
Over 9 out of 10 patients are covered for ZENPEP2
-ZENPEP insurance coverage through commercial is 92% and through Medicare Part D is 95%2
-88% of patients have no prior authorization or step-edit requirements3
-Coverage is the same for all dosage strengths3*
*Data are not a guarantee of coverage, or partial or full payment, by any payers listed. Actual benefits determined by respective plan administrators. Insurer plans, coverage criteria, and formularies are subject to change without notice. Check each patient’s coverage with applicable insurer. Nestlé Health Science does not endorse any individual plans. Formulary coverage does not imply efficacy or safety.
ZENPEP Dosing Calculator
Calculate the ZENPEP dose in 3 easy steps.
Use the app below to calculate the per-meal ZENPEP dose for your patients with EPI due to CF or other conditions. ZENPEP is not interchangeable with any other pancrelipase product. Therapy should be initiated at the lowest recommended dose and gradually increased. The dosage of ZENPEP should be individualized based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet. Dosing should not exceed the recommended maximum dosage set forth by the Cystic Fibrosis Foundation Consensus Conferences Guidelines.
Step 1 / Patient Age
Step 2 / Weight or Dietary Fat-Based Dosing
Step 3 / Recommended Lipase Units/kg Body
Step 4 / Result!
DISCLAIMER: By using this dosing calculator, you agree to the following: The dosing calculator is being provided "AS IS" and is intended for healthcare professional (HCP) use only. The dosing calculator is to be used only in conjunction with ZENPEP (pancrelipase) delayed-release capsules. All calculations should be confirmed before use. The information being provided is not a substitute for clinical judgment. While the tool attempts to be as accurate as possible, it should not be relied upon as being comprehensive and error-free. Neither Nestlé Health Science, nor any party involved in the publication of this site, shall be liable to you or others for any decisions made or actions taken by you or others in reliance of this information. The user assumes all responsibility and risk for the use of this tool.
If you are not an HCP and have questions about ZENPEP dosing, please contact your HCP.
References: 1. ZENPEP. Package insert. Nestlé Health Science; 2020. 2. MMIT Data on File. Nestlé Health Science. Accessed February 1, 2021. 3. MMIT Data on File. Nestlé Health Science. Accessed November 3, 2020.