FAQs

Common Questions

ZENPEP (pancrelipase) is a combination of porcine-derived lipases, proteases, and amylases indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis (CF), or other conditions.
Signs and symptoms of maldigestion or malabsorption associated with EPI include steatorrhea, abdominal pain, bloating, flatulence, or weight loss. Symptoms include frequent, soft, watery, bulky, oily, foul-smelling stools, or diarrhea.1,4
In addition to the treatment of causative factors, there are 2 key goals for managing EPI — improving digestion and absorption of nutrients and relieving GI signs and symptoms of EPI. Management includes lifestyle and dietary modifications, vitamin and nutrient supplementation, and pancreatic enzyme therapy.2,3-6
Give ZENPEP right before each feeding of formula or breast milk, but do not mix the capsule contents directly into formula or breast milk. If your infant feeds a lot throughout the day, be careful not to go over the total daily dose.

Until your infant is old enough to swallow capsules whole, open the ZENPEP capsule and sprinkle the contents directly into your infant’s mouth, or onto food. If you’re sprinkling ZENPEP contents into your infant’s mouth, always give your infant enough breast milk or formula to completely swallow the ZENPEP contents right away.

If you’re sprinkling ZENPEP contents onto food, always give the ZENPEP and food mixture to your infant right away. Use a small amount of acidic food, such as applesauce or pureed bananas or pears. This should be the kind of baby food jars that you buy at the store, or other food recommended by your doctor. Do not mix ZENPEP directly into formula or breast milk. Liquid is needed whether you are giving ZENPEP with food or directly into your infant’s mouth.

After giving ZENPEP to your infant, remember to look in his or her mouth to make sure that all of the medicine has been swallowed.

  • If you have trouble swallowing capsules, open the capsules and sprinkle the beads on a small amount of acidic food such as applesauce, pureed bananas or pears. Ask your doctor about other foods you can mix with ZENPEP.
  • If you sprinkle ZENPEP on food, swallow it right after you mix it. Do not store ZENPEP that is mixed with food.
  • Swallow the ZENPEP and food mixture right away followed with water or juice. Make sure the medicine is swallowed completely.
  • If you forget to take ZENPEP, call your doctor or wait until your next meal and take your usual number of capsules. Do not make up for missed doses. Take your next dose at the usual time.
Do not give your infant more ZENPEP in a day than what your doctor tells you. This is your infant’s total daily dose, which your doctor has calculated for you.
  • Swallow ZENPEP capsules whole and take them with enough liquid to swallow them right away.
  • If you have trouble swallowing capsules, open the capsules and sprinkle the beads on a small amount of acidic food such as applesauce, pureed bananas or pears. Ask your doctor about other foods you can mix with ZENPEP.
  • If you sprinkle ZENPEP on food, swallow it right after you mix it. Do not store ZENPEP that is mixed with food.
  • Swallow the ZENPEP and food mixture right away followed with water or juice. Make sure the medicine is swallowed completely.

If you forget to take ZENPEP, call your doctor or wait until your next meal and take your usual number of capsules. Do not make up for missed doses. Take your next dose at the usual time.

  • Store ZENPEP at room temperature (68° to 77°F; 20° to 25°C). Avoid heat.
  • After opening the bottle, keep it closed tightly between doses.
  • DO NOT eat or throw away the packet (desiccant) in your medicine bottle. This packet will protect your medicine from moisture.
  • Store ZENPEP in a dry place.
  • Keep ZENPEP and all medicines out of the reach of children.