How ZENPEP® Works

ZENPEP provides delayed release to optimize delivery1,2

Beads and microbeads are designed to protect and deliver enzymes to the neutralized chyme within the proximal small intestine to enhance nutrient absorption. ZENPEP is formulated to optimize enzyme bioavailability and mimic normal pancreatic function.1-7

Each bead is treated with an enteric coating that1-3:

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1 Inhibits Degradation

1Minimizes destruction or inactivation in gastric acid

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2 Targets enzyme release

2Allows for delayed release of enzymes until they are in the proximal small intestine (at pH >5.5, based on in vivo studies)

Once released, the enzymes catalyze the hydrolysis of fats, proteins, and carbohydrates.1

ZENPEP was studied without the use of PPIs, H2-blockers, or motility agents.

As early as 15 minutes after ingestion, ZENPEP delivers lipase straight to the site of fat absorption during meals, with statistical significance seen at 30 minutes2*

*When compared with duodenal lipase release without ZENPEP.

PPI=proton pump inhibitor.

References: 1. ZENPEP. Package insert. Nestlé Health Science; 2020. 2. Lieb JG 2nd, Patel D, Karnik N, Toskes PP. Study of the gastrointestinal bioavailability of a pancreatic extract product (Zenpep) in chronic pancreatitis patients with exocrine pancreatic insufficiency. Pancreatology. 2020;20(6):1092-1102. doi:10.1016/j.pan.2020.07.007 3. Karnik NP, Jan A. Pancrelipase. NCBI Bookshelf. Updated April 21, 2020. Accessed November 9, 2020. www.ncbi.nlm.nih.gov/books/NBK534847 4. Data on File. ZENPEP Dossier. 2014. 5. Data on File. Shape Patent. 2010. 6. Domínguez-Muñoz JE. Pancreatic exocrine insufficiency: diagnosis and treatment. J Gastroenterol Hepatol. 2011;26(suppl 2):12-16. doi:10.1111/j.1440-1746.2010.06600.x 7. Keller J, Layer P. Human pancreatic exocrine response to nutrients in health and disease. Gut. 2005;54(suppl 6):vi1-vi28. doi:10.1136/gut.2005.065946