This site is intended
for U.S. residents only.

How to give ZENPEP to infants

If your infant has been prescribed ZENPEP for exocrine pancreatic insufficiency (EPI) due to Cystic Fibrosis (CF) or other conditions, the doctor will have given you instructions for how it should be administered.

You should always give ZENPEP exactly as your doctor tells you to.

If you are looking for more information, these are important things to remember about taking ZENPEP or giving it to your infant:

When to give ZENPEP to your infant

Give ZENPEP right before each feeding of formula or breast milk, but do not mix the capsule contents directly into formula or breast milk. If your infant feeds a lot throughout the day, be careful not to go over the total daily dose.

How to give your infant ZENPEP

Until your infant is old enough to swallow capsules whole, open the ZENPEP capsule and sprinkle the contents directly into your infant’s mouth, or onto food. If you’re sprinkling ZENPEP contents into your infant’s mouth, always give your infant enough breast milk or formula to completely swallow the ZENPEP contents right away.

If you’re sprinkling ZENPEP contents onto food, always give the ZENPEP and food mixture to your infant right away. Use a small amount of acidic foods, such as applesauce or pureed bananas or pears. This should be the kind of baby food jars that you buy at the store, or other food recommended by your doctor. Do not mix ZENPEP directly into formula or breast milk. Liquid is needed whether you are giving ZENPEP with food or directly into your infant’s mouth.

After giving ZENPEP to your infant, remember to look in his or her mouth to make sure that all of the medicine has been swallowed.

Swallowing ZENPEP capsule contents

Do not crush ZENPEP or let your infant chew or suck on the capsules’ contents. The enzymes in the capsules should be swallowed quickly, and not stay or be held in your infant’s mouth. Crushing, chewing, or holding the ZENPEP contents in the mouth may cause irritation in the mouth or change the way ZENPEP works in the body.

Your infant’s daily ZENPEP dose

Do not give your infant more ZENPEP in a day than what your doctor tells you. This is your infant’s total daily dose, which your doctor has calculated for you.

How to store ZENPEP

Keep ZENPEP and all medicines out of the reach of children.

LEARN ABOUT ZENPEP PATIENT
SUPPORT AND SAVINGS PROGRAMS

IMPORTANT RISK INFORMATION

What is the most important information I should know about ZENPEP?
ZENPEP® (pancrelipase) may increase your chance of having a rare bowel disorder called fibrosing colonopathy. This condition is serious and may require surgery. The risk of having fibrosing colonopathy may be reduced by following the dosing instructions your doctor gave you. Call your doctor right away if you have any unusual or severe: stomach area (abdominal) pain, bloating, trouble passing stool (having bowel movements), nausea, vomiting, or diarrhea.
Take ZENPEP exactly as prescribed. Do not take more or less ZENPEP than directed by your doctor.
Before you take ZENPEP, tell your doctor:
If you are allergic to pork (pig) products; have a history of blockage of your intestines, or scarring or thickening of your bowel wall (fibrosing colonopathy); have gout, kidney disease, or high blood uric acid (hyperuricemia); have trouble swallowing capsules; have any other medical condition; are pregnant or plan to become pregnant; are breastfeeding or plan to breastfeed.
About all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
How should I take ZENPEP?
Take ZENPEP exactly as your doctor tells you.
Do not crush or chew the ZENPEP capsule or its contents, and do not hold the capsule or contents in your mouth. This may cause irritation in your mouth or change the way ZENPEP works in your body. See Patient Medication Guide and talk to your doctor for additional directions.
Side Effects
ZENPEP may cause serious side effects, including worsening of swollen, painful joints (gout) caused by an increase in blood uric acid levels and allergic reactions including trouble with breathing, skin rashes, or swollen lips. Call your doctor right away if you have any of these symptoms.
The most common side effects of ZENPEP include belly pain, gas, and headache.
ZENPEP and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.
Tell your doctor if you have any side effect that bothers you or does not go away. These are not all the possible side effects of ZENPEP.
For more information, ask your doctor or pharmacist.
What is ZENPEP?
ZENPEP is a prescription medicine for people who cannot digest food normally because their pancreas does not make enough enzymes. ZENPEP may help your body use fats, proteins, and sugars from food. ZENPEP contains a mixture of digestive enzymes (lipases, proteases, and amylases) from pig pancreas. ZENPEP is safe and effective in children.
Please also see Patient Medication Guide within the full Prescribing Information

IMPORTANT RISK INFORMATION

What is the most important information I should know about ZENPEP?
ZENPEP® (pancrelipase) may increase your chance of having a rare bowel disorder called fibrosing colonopathy. This condition is serious and may require surgery. The risk of having fibrosing colonopathy may be reduced by following the dosing instructions your doctor gave you. Call your doctor right away if you have any unusual or severe: stomach area (abdominal) pain, bloating, trouble passing stool (having bowel movements), nausea, vomiting, or diarrhea.
Take ZENPEP exactly as prescribed. Do not take more or less ZENPEP than directed by your doctor.
Before you take ZENPEP, tell your doctor:
If you are allergic to pork (pig) products; have a history of blockage of your intestines, or scarring or thickening of your bowel wall (fibrosing colonopathy); have gout, kidney disease, or high blood uric acid (hyperuricemia); have trouble swallowing capsules; have any other medical condition; are pregnant or plan to become pregnant; are breastfeeding or plan to breastfeed.
About all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
How should I take ZENPEP?
Take ZENPEP exactly as your doctor tells you.
Do not crush or chew the ZENPEP capsule or its contents, and do not hold the capsule or contents in your mouth. This may cause irritation in your mouth or change the way ZENPEP works in your body. See Patient Medication Guide and talk to your doctor for additional directions.
Side Effects
ZENPEP may cause serious side effects, including worsening of swollen, painful joints (gout) caused by an increase in blood uric acid levels and allergic reactions including trouble with breathing, skin rashes, or swollen lips. Call your doctor right away if you have any of these symptoms.
The most common side effects of ZENPEP include belly pain, gas, and headache.
ZENPEP and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.
Tell your doctor if you have any side effect that bothers you or does not go away. These are not all the possible side effects of ZENPEP.
For more information, ask your doctor or pharmacist.
What is ZENPEP?
ZENPEP is a prescription medicine for people who cannot digest food normally because their pancreas does not make enough enzymes. ZENPEP may help your body use fats, proteins, and sugars from food. ZENPEP contains a mixture of digestive enzymes (lipases, proteases, and amylases) from pig pancreas. ZENPEP is safe and effective in children.
Please also see Patient Medication Guide within the full Prescribing Information.