Recommended Dosing

Each ZENPEP capsule strength contains the specified amount of the enzymes lipase, protease, and amylase

Not Actual Capsule Images

How should I take ZENPEP?

Remember to always follow your doctor's instructions when taking ZENPEP or giving it to your child. Always take ZENPEP exactly as your doctor tells you.

Infants (up to 12 months)
Children & Adults

Give ZENPEP right before each feeding of formula or breast milk.

Do not mix ZENPEP capsule contents directly into formula or breast milk.

Open the capsule and sprinkle the contents on a small amount of applesauce, pureed bananas, or pears. These foods should be the kind found in baby food jars that you buy at the store, or other food recommended by your doctor. You may also sprinkle the contents directly into your child's mouth.

If you sprinkle the ZENPEP on food, give the ZENPEP and food mixture to your child right away.

Give your child enough liquid to completely swallow the ZENPEP contents or the ZENPEP and food mixture.

Look in your child's mouth to make sure that all of the medicine has been swallowed.

Swallow ZENPEP capsules whole and take them with enough liquid to swallow them right away.

If you have trouble swallowing capsules, open the capsules and sprinkle the beads on a small amount of acidic food such as applesauce, pureed bananas, or pears. Ask your doctor about other foods you can mix with ZENPEP.

If you sprinkle ZENPEP on food, swallow it right after you mix it. Do not store ZENPEP that is mixed with food.

Swallow the ZENPEP and food mixture right away followed with water or juice. Make sure the medicine is swallowed completely.

If you forget to take ZENPEP, call your doctor or wait until your next meal and take your usual number of capsules. Do not make up for missed doses. Take your next dose at the usual time.

Do not crush or chew the ZENPEP capsules or its contents, and do not hold the capsule or contents in your mouth. Crushing, chewing, or holding the ZENPEP capsules in your mouth may cause irritation in your mouth or change the way ZENPEP works in your body.

Take Zenpep exactly as your doctor tells you.

Do not take more capsules in a day than the number your doctor tells you.

Always take Zenpep with a meal or snack. If you eat a lot of meals or snacks in a day, be careful not to go over your total daily dose.

For Healthcare Professionals

The information provided in this website is intended for U.S. healthcare professionals only.

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IMPORTANT RISK INFORMATION
What is the most important information I should know about ZENPEP?
  • ZENPEP® (pancrelipase) may increase your chance of having a rare bowel disorder called fibrosing colonopathy. This condition is serious and may require surgery. The risk of having fibrosing colonopathy may be reduced by following the dosing instructions your doctor gave you. Call your doctor right away if you have any unusual or severe: stomach area (abdominal) pain, bloating, trouble passing stool (having bowel movements), nausea, vomiting, or diarrhea.
  • Take ZENPEP exactly as prescribed. Do not take more or less ZENPEP than directed by your doctor.
Before you take ZENPEP, tell your doctor:
  • If you are allergic to pork (pig) products; have a history of blockage of your intestines, or scarring or thickening of your bowel wall (fibrosing colonopathy); have gout, kidney disease, or high blood uric acid (hyperuricemia); have trouble swallowing capsules; have any other medical condition; are pregnant or plan to become pregnant; are breastfeeding or plan to breastfeed.
  • About all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
How should I take ZENPEP?
  • Take ZENPEP exactly as your doctor tells you.
  • Do not crush or chew the ZENPEP capsule or its contents, and do not hold the capsule or contents in your mouth. This may cause irritation in your mouth or change the way ZENPEP works in your body. See Medication Guide and talk to your doctor for additional directions.
Side Effects
  • ZENPEP may cause serious side effects, including worsening of swollen, painful joints (gout) caused by an increase in blood uric acid levels and allergic reactions including trouble with breathing, skin rashes, or swollen lips. Call your doctor right away if you have any of these symptoms.
  • The most common side effects of ZENPEP include belly pain, gas, and headache.
  • ZENPEP and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.
  • Tell your doctor if you have any side effect that bothers you or does not go away. These are not all the possible side effects of ZENPEP. For more information, ask your doctor or pharmacist.
What is ZENPEP?

    ZENPEP is a prescription medicine for people who cannot digest food normally because their pancreas does not make enough enzymes. ZENPEP may help your body use fats, proteins, and sugars from food. ZENPEP contains a mixture of digestive enzymes (lipases, proteases, and amylases) from pig pancreas. ZENPEP is safe and effective in children.

    Please also see Medication Guide within the full Prescribing Information.

IMPORTANT RISK INFORMATION More Less
What is the most important information I should know about ZENPEP?
  • ZENPEP® (pancrelipase) may increase your chance of having a rare bowel disorder called fibrosing colonopathy. This condition is serious and may require surgery. The risk of having fibrosing colonopathy may be reduced by following the dosing instructions your doctor gave you. Call your doctor right away if you have any unusual or severe: stomach area (abdominal) pain, bloating, trouble passing stool (having bowel movements), nausea, vomiting, or diarrhea.
  • Take ZENPEP exactly as prescribed. Do not take more or less ZENPEP than directed by your doctor.
Before you take ZENPEP, tell your doctor:
  • If you are allergic to pork (pig) products; have a history of blockage of your intestines, or scarring or thickening of your bowel wall (fibrosing colonopathy); have gout, kidney disease, or high blood uric acid (hyperuricemia); have trouble swallowing capsules; have any other medical condition; are pregnant or plan to become pregnant; are breastfeeding or plan to breastfeed.
  • About all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
How should I take ZENPEP?
  • Take ZENPEP exactly as your doctor tells you.
  • Do not crush or chew the ZENPEP capsule or its contents, and do not hold the capsule or contents in your mouth. This may cause irritation in your mouth or change the way ZENPEP works in your body. See Medication Guide and talk to your doctor for additional directions.
Side Effects
  • ZENPEP may cause serious side effects, including worsening of swollen, painful joints (gout) caused by an increase in blood uric acid levels and allergic reactions including trouble with breathing, skin rashes, or swollen lips. Call your doctor right away if you have any of these symptoms.
  • The most common side effects of ZENPEP include belly pain, gas, and headache.
  • ZENPEP and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.
  • Tell your doctor if you have any side effect that bothers you or does not go away. These are not all the possible side effects of ZENPEP. For more information, ask your doctor or pharmacist.
What is ZENPEP?

    ZENPEP is a prescription medicine for people who cannot digest food normally because their pancreas does not make enough enzymes. ZENPEP may help your body use fats, proteins, and sugars from food. ZENPEP contains a mixture of digestive enzymes (lipases, proteases, and amylases) from pig pancreas. ZENPEP is safe and effective in children.

    Please also see Medication Guide within the full Prescribing Information.