DISCLAIMER: By using this dosing calculator, you agree to the following: The dosing calculator is being provided "AS IS" and is intended for healthcare professional (HCP) use only. The dosing calculator is to be used only in conjunction with ZENPEP® (pancrelipase) delayed-release capsules. All calculations should be confirmed before use. The information being provided is not a substitute for clinical judgement. While the tool attempts to be as accurate as possible, it should not be relied upon as being comprehensive and error-free. Nestlé Health Science, nor any party involved in the publication of this site, shall be liable to you or others for any decisions made or actions taken by you or others in reliance of this information. The user assumes all responsibility and risk for the use of this tool.
If you are not an HCP and have questions about ZENPEP dosing, please contact your HCP.
Dosage and Administration
ZENPEP is not interchangeable with any other pancrelipase product.
Therapy should be initiated at the lowest recommended dose and gradually increased. The dosage of ZENPEP should be individualized based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet.
Infants (up to 12 months)
Infants may be given 3,000 lipase units (one capsule) per 120 mL of formula or per breastfeeding
Do not mix ZENPEP capsule contents directly into formula or breast milk prior to administration
Children Older than 12 Months and Younger than 4 Years
Enzyme dosing should begin with 1,000 lipase units/kg of body weight per meal to a maximum of 2,500 lipase units/kg of body weight per meal (or less than or equal to 10,000 lipase units/kg of body weight per day), or less than 4,000 lipase units/g fat ingested per day
Children 4 Years and Older and Adults
Enzyme dosing should begin with 500 lipase units/kg of body weight per meal to a maximum of 2,500 lipase units/kg of body weight per meal (or less than or equal to 10,000 lipase units/kg of body weight per day), or less than 4,000 lipase units/g fat ingested per day
Usually, half of the prescribed ZENPEP dose for an individualized full meal should be given with each snack. The total daily dose should reflect approximately three meals plus two or three snacks per day
Limitations on Dosing
Dosing should not exceed the recommended maximum dosage set forth by the Cystic Fibrosis Foundation Consensus Conferences Guidelines
ZENPEP should be swallowed whole. ZENPEP capsules and capsule contents should not be crushed or chewed
For infants or patients unable to swallow intact capsules, the contents may be sprinkled on small amounts of soft acidic food, eg, applesauce
For children and adults, ZENPEP should be taken during meals or snacks, with sufficient fluid
For complete information on dosage and administration, please see full