Dosage
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ZENPEP is not interchangeable with any other pancrelipase product.Therapy should be initiated at the lowest recommended dose and gradually increased. The dosage of ZENPEP should be individualized based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet.
Infants (up to 12 months)
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Infants may be given 3,000 lipase units (one capsule) per 120 mL of formula or per breastfeeding
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Do not mix ZENPEP capsule contents directly into formula or breast milk prior to administration
Children Older than 12 Months and Younger than 4 Years
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Enzyme dosing should begin with 1,000 lipase units/kg of body weight per meal to a maximum of 2,500 lipase units/kg of body weight per meal (or ≤ 10,000 lipase units/kg of body weight per day), or less than 4,000 lipase units/g fat ingested per day
Children 4 Years and Older and Adults
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Enzyme dosing should begin with 500 lipase units/kg of body weight per meal to a maximum of 2,500 lipase units/kg of body weight per meal (or ≤ 10,000 lipase units/kg of body weight per day), or less than 4,000 lipase units/g fat ingested per day
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Usually half of the prescribed ZENPEP dose for an individualized full meal should be given with each snack. The total daily dose should reflect approximately 3 meals plus 2 or 3 snacks per day
Limitations on Dosing
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Dosing should not exceed the recommended maximum dosage set forth by the Cystic Fibrosis Foundation Consensus Conferences Guidelines
For further information on dosing and administartion, please see ZENPEP full
Prescribing Information.