- Fibrosing colonopathy is a rare serious adverse reaction associated with high-dose use of pancreatic enzyme replacement. Exercise caution when doses of ZENPEP exceed 2500 lipase units/kg of body weight per meal (or greater than 10,000 lipase units/kg of body weight per day).
- To avoid irritation of oral mucosa, do not chew ZENPEP or retain in the mouth.
- Exercise caution when prescribing ZENPEP to patients with gout, renal impairment, or hyperuricemia
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